Diaminocarbene Complexes of Palladium(II) Containing 2-Aminooxazole and 2-Aminothiazole Heterocyclic Ligands as Potential Antitumor Agents
نویسندگان
چکیده
A new diaminocarbene cis-palladium(II) complex containing a 2-aminobenzoxazole ligand was synthesized by reacting cis-[PdCl2(CNCy)2] and 2-aminobenzoxazole. The structure composition of the obtained were proven NMR spectroscopy high-resolution mass spectrometry. cytotoxicities structurally similar palladium(II) complexes 2-aminothiazole tested against human cancer cells various histogenesis (MCF-7, HL60, HeLa, DLD1, A431). activities several higher than those reference drug cisplatin free ligands, i.e., 2-aminooxazole substituted 2-aminothiazoles.
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ژورنال
عنوان ژورنال: Pharmaceutical Chemistry Journal
سال: 2021
ISSN: ['0091-150X', '1573-9031']
DOI: https://doi.org/10.1007/s11094-021-02393-1